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1.

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.

Van Buren, Eric; Radicioni, Giorgia; Lester, Sarah; O'Neal, Wanda K; Dang, Hong; Kasela, Silva; Garudadri, Suresh; Curtis, Jeffrey L; Han, MeiLan K; Krishnan, Jerry A; Wan, Emily S; Silverman, Edwin K; Hastie, Annette; Ortega, Victor E; Lappalainen, Tuuli; Nawijn, Martijn C; Berge, Maarten van den; Christenson, Stephanie A; Li, Yun; Cho, Michael H; Kesimer, Mehmet; Kelada, Samir N P.

PLoS Genet ; 19(6): e1010445, 2023 06.

Article in English | MEDLINE | ID: mdl-37352370

2.

The Effect of Chronic Altitude Exposure on COPD Outcomes in the SPIROMICS Cohort.

Suri, Rajat; Markovic, Daniela; Woo, Han; Arjomandi, Mehrdad; Barr, R Graham; Bowler, Russell P; Criner, Gerard; Curtis, Jeffrey L; Dransfield, Mark T; Drummond, M Bradley; Fortis, Spyridon; Han, MeiLan K; Hoffman, Eric A; Kaner, Robert J; Kaufman, Joel D; Krishnan, Jerry A; Martinez, Fernando J; Ohar, Jill; Ortega, Victor E; Paine Iii, Robert; Soler, Xavier; Woodruff, Prescott G; Hansel, Nadia N; Cooper, Christopher B; Tashkin, Donald P; Buhr, Russell G; Barjaktarevic, Igor Z.

Am J Respir Crit Care Med ; 2024 Mar 20.

Article in English | MEDLINE | ID: mdl-38507607

3.

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD.

Opron, Kristopher; Begley, Lesa A; Erb-Downward, John R; Li, Gen; Alexis, Neil E; Barjaktarevic, Igor; Barr, R Graham; Bleecker, Eugene R; Boucher, Richard; Bowler, Russell P; Christenson, Stephanie A; Comellas, Alejandro P; Criner, Gerard; Cooper, Christopher B; Couper, David; Galban, Craig J; Han, MeiLan K; Hastie, Annette; Hatt, Charles; Hoffman, Eric A; Kaner, Robert J; Kesimer, Mehmet; Krishnan, Jerry A; LaFon, David C; Martinez, Fernando J; Ortega, Victor E; Peters, Stephen P; Paine Iii, Robert; Putcha, Nirupama; Woodruff, Prescott G; Huffnagle, Gary B; Kozik, Ariangela J; Curtis, Jeffrey L; Huang, Yvonne J.

Am J Respir Crit Care Med ; 2024 Jan 23.

Article in English | MEDLINE | ID: mdl-38261629

4.

Epigenetic Reprogramming Drives Epithelial Disruption in Chronic Obstructive Pulmonary Disease.

Yeung-Luk, Bonnie H; Wally, Ara; Swaby, Carter; Jauregui, Sofia; Lee, Esther; Zhang, Rachel; Chen, Daniel; Luk, Sean H; Upadya, Nisha; Tieng, Ethan; Wilmsen, Kai; Sherman, Ethan; Sudhakar, Dheeksha; Luk, Matthew; Shrivastav, Abhishek Kumar; Cao, Shuo; Ghosh, Baishakhi; Christenson, Stephanie A; Huang, Yvonne J; Ortega, Victor E; Biswal, Shyam; Tang, Wan-Yee; Sidhaye, Venkataramana K.

Am J Respir Cell Mol Biol ; 70(3): 165-177, 2024 Mar.

Article in English | MEDLINE | ID: mdl-37976469

5.

Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma.

Hastie, Annette T; Bishop, Andrew C; Khan, Mohammad S; Bleecker, Eugene R; Castro, Mario; Denlinger, Loren C; Erzurum, Serpil C; Fahy, John V; Israel, Elliot; Levy, Bruce D; Mauger, David T; Meyers, Deborah A; Moore, Wendy C; Ortega, Victor E; Peters, Stephen P; Wenzel, Sally E; Steele, Chad H.

Clin Exp Allergy ; 54(4): 265-277, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38253462

6.

Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement.

Bhakta, Nirav R; Bime, Christian; Kaminsky, David A; McCormack, Meredith C; Thakur, Neeta; Stanojevic, Sanja; Baugh, Aaron D; Braun, Lundy; Lovinsky-Desir, Stephanie; Adamson, Rosemary; Witonsky, Jonathan; Wise, Robert A; Levy, Sean D; Brown, Robert; Forno, Erick; Cohen, Robyn T; Johnson, Meshell; Balmes, John; Mageto, Yolanda; Lee, Cathryn T; Masekela, Refiloe; Weiner, Daniel J; Irvin, Charlie G; Swenson, Erik R; Rosenfeld, Margaret; Schwartzstein, Richard M; Agrawal, Anurag; Neptune, Enid; Wisnivesky, Juan P; Ortega, Victor E; Burney, Peter.

Am J Respir Crit Care Med ; 207(8): 978-995, 2023 04 15.

Article in English | MEDLINE | ID: mdl-36973004

7.

A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.

Moll, Matthew; Peljto, Anna L; Kim, John S; Xu, Hanfei; Debban, Catherine L; Chen, Xianfeng; Menon, Aravind; Putman, Rachel K; Ghosh, Auyon J; Saferali, Aabida; Nishino, Mizuki; Hatabu, Hiroto; Hobbs, Brian D; Hecker, Julian; McDermott, Gregory; Sparks, Jeffrey A; Wain, Louise V; Allen, Richard J; Tobin, Martin D; Raby, Benjamin A; Chun, Sung; Silverman, Edwin K; Zamora, Ana C; Ortega, Victor E; Garcia, Christine K; Barr, R Graham; Bleecker, Eugene R; Meyers, Deborah A; Kaner, Robert J; Rich, Stephen S; Manichaikul, Ani; Rotter, Jerome I; Dupuis, Josée; O'Connor, George T; Fingerlin, Tasha E; Hunninghake, Gary M; Schwartz, David A; Cho, Michael H.

Am J Respir Crit Care Med ; 208(7): 791-801, 2023 10 01.

Article in English | MEDLINE | ID: mdl-37523715

8.

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

Lackey, Lela; Coria, Aaztli; Ghosh, Auyon J; Grayeski, Phil; Hatfield, Abigail; Shankar, Vijay; Platig, John; Xu, Zhonghui; Ramos, Silvia B V; Silverman, Edwin K; Ortega, Victor E; Cho, Michael H; Hersh, Craig P; Hobbs, Brian D; Castaldi, Peter; Laederach, Alain.

PLoS Genet ; 17(11): e1009912, 2021 11.

Article in English | MEDLINE | ID: mdl-34784346

9.

Prolonged, physiologically relevant nicotine concentrations in the airways of smokers.

Esther, Charles R; O'Neal, Wanda K; Alexis, Neil E; Koch, Abigail L; Cooper, Christopher B; Barjaktarevic, Igor; Raffield, Laura M; Bowler, Russel P; Comellas, Alejandro P; Peters, Stephen P; Hastie, Annette T; Curtis, Jeffrey L; Ronish, Bonnie; Ortega, Victor E; Wells, J Michael; Halper-Stromberg, Eitan; Rennard, Stephen I; Boucher, Richard C.

Am J Physiol Lung Cell Mol Physiol ; 324(1): L32-L37, 2023 01 01.

Article in English | MEDLINE | ID: mdl-36342131

10.

Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS.

LaFon, David C; Woo, Han; Fedarko, Neal; Azar, Antoine; Hill, Harry; Tebo, Anne E; Martins, Thomas B; Han, MeiLan K; Krishnan, Jerry A; Ortega, Victor E; Barjaktarevic, Igor; Kaner, Robert J; Hastie, Annette; O'Neal, Wanda K; Couper, David; Woodruff, Prescott G; Curtis, Jeffrey L; Hansel, Nadia N; Nahm, Moon H; Dransfield, Mark T; Putcha, Nirupama.

Clin Immunol ; 250: 109324, 2023 05.

Article in English | MEDLINE | ID: mdl-37030524

11.

Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans.

Angelini, Elsa D; Yang, Jie; Balte, Pallavi P; Hoffman, Eric A; Manichaikul, Ani W; Sun, Yifei; Shen, Wei; Austin, John H M; Allen, Norrina B; Bleecker, Eugene R; Bowler, Russell; Cho, Michael H; Cooper, Christopher S; Couper, David; Dransfield, Mark T; Garcia, Christine Kim; Han, MeiLan K; Hansel, Nadia N; Hughes, Emlyn; Jacobs, David R; Kasela, Silva; Kaufman, Joel Daniel; Kim, John Shinn; Lappalainen, Tuuli; Lima, Joao; Malinsky, Daniel; Martinez, Fernando J; Oelsner, Elizabeth C; Ortega, Victor E; Paine, Robert; Post, Wendy; Pottinger, Tess D; Prince, Martin R; Rich, Stephen S; Silverman, Edwin K; Smith, Benjamin M; Swift, Andrew J; Watson, Karol E; Woodruff, Prescott G; Laine, Andrew F; Barr, R Graham.

Thorax ; 78(11): 1067-1079, 2023 11.

Article in English | MEDLINE | ID: mdl-37268414

12.

Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease.

Madapoosi, Siddharth S; Cruickshank-Quinn, Charmion; Opron, Kristopher; Erb-Downward, John R; Begley, Lesa A; Li, Gen; Barjaktarevic, Igor; Barr, R Graham; Comellas, Alejandro P; Couper, David J; Cooper, Christopher B; Freeman, Christine M; Han, MeiLan K; Kaner, Robert J; Labaki, Wassim; Martinez, Fernando J; Ortega, Victor E; Peters, Stephen P; Paine, Robert; Woodruff, Prescott; Curtis, Jeffrey L; Huffnagle, Gary B; Stringer, Kathleen A; Bowler, Russell P; Esther, Charles R; Reisdorph, Nichole; Huang, Yvonne J.

Am J Respir Crit Care Med ; 206(4): 427-439, 2022 08 15.

Article in English | MEDLINE | ID: mdl-35536732

13.

Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma.

Cardet, Juan Carlos; Kim, Donghwa; Bleecker, Eugene R; Casale, Thomas B; Israel, Elliot; Mauger, David; Meyers, Deborah A; Ampleford, Elizabeth; Hawkins, Gregory A; Tu, Yaping; Liggett, Stephen B; Ortega, Victor E.

J Allergy Clin Immunol ; 150(3): 721-726.e1, 2022 09.

Article in English | MEDLINE | ID: mdl-35398411

14.

The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.

Georas, Steve N; Wright, Rosalind J; Ivanova, Anastasia; Israel, Elliot; LaVange, Lisa M; Akuthota, Praveen; Carr, Tara F; Denlinger, Loren C; Fajt, Merritt L; Kumar, Rajesh; O'Neal, Wanda K; Phipatanakul, Wanda; Szefler, Stanley J; Aronica, Mark A; Bacharier, Leonard B; Burbank, Allison J; Castro, Mario; Crotty Alexander, Laura; Bamdad, Julie; Cardet, Juan Carlos; Comhair, Suzy A A; Covar, Ronina A; DiMango, Emily A; Erwin, Kim; Erzurum, Serpil C; Fahy, John V; Gaffin, Jonathan M; Gaston, Benjamin; Gerald, Lynn B; Hoffman, Eric A; Holguin, Fernando; Jackson, Daniel J; James, John; Jarjour, Nizar N; Kenyon, Nicholas J; Khatri, Sumita; Kirwan, John P; Kraft, Monica; Krishnan, Jerry A; Liu, Andrew H; Liu, Mark C; Marquis, M Alison; Martinez, Fernando; Mey, Jacob; Moore, Wendy C; Moy, James N; Ortega, Victor E; Peden, David B; Pennington, Emily; Peters, Michael C.

J Allergy Clin Immunol ; 149(2): 488-516.e9, 2022 02.

Article in English | MEDLINE | ID: mdl-34848210

15.

Longitudinal Follow-Up of Participants With Tobacco Exposure and Preserved Spirometry.

McKleroy, William; Shing, Tracie; Anderson, Wayne H; Arjomandi, Mehrdad; Awan, Hira Anees; Barjaktarevic, Igor; Barr, R Graham; Bleecker, Eugene R; Boscardin, John; Bowler, Russell P; Buhr, Russell G; Criner, Gerard J; Comellas, Alejandro P; Curtis, Jeffrey L; Dransfield, Mark; Doerschuk, Claire M; Dolezal, Brett A; Drummond, M Bradley; Han, MeiLan K; Hansel, Nadia N; Helton, Kinsey; Hoffman, Eric A; Kaner, Robert J; Kanner, Richard E; Krishnan, Jerry A; Lazarus, Stephen C; Martinez, Fernando J; Ohar, Jill; Ortega, Victor E; Paine, Robert; Peters, Stephen P; Reinhardt, Joseph M; Rennard, Stephen; Smith, Benjamin M; Tashkin, Donald P; Couper, David; Cooper, Christopher B; Woodruff, Prescott G.

JAMA ; 330(5): 442-453, 2023 08 01.

Article in English | MEDLINE | ID: mdl-37526720

16.

Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

Wechsler, Michael E; Szefler, Stanley J; Ortega, Victor E; Pongracic, Jacqueline A; Chinchilli, Vernon; Lima, John J; Krishnan, Jerry A; Kunselman, Susan J; Mauger, David; Bleecker, Eugene R; Bacharier, Leonard B; Beigelman, Avraham; Benson, Mindy; Blake, Kathryn V; Cabana, Michael D; Cardet, Juan-Carlos; Castro, Mario; Chmiel, James F; Covar, Ronina; Denlinger, Loren; DiMango, Emily; Fitzpatrick, Anne M; Gentile, Deborah; Grossman, Nicole; Holguin, Fernando; Jackson, Daniel J; Kumar, Harsha; Kraft, Monica; LaForce, Craig F; Lang, Jason; Lazarus, Stephen C; Lemanske, Robert F; Long, Dayna; Lugogo, Njira; Martinez, Fernando; Meyers, Deborah A; Moore, Wendy C; Moy, James; Naureckas, Edward; Olin, J Tod; Peters, Stephen P; Phipatanakul, Wanda; Que, Loretta; Raissy, Hengameh; Robison, Rachel G; Ross, Kristie; Sheehan, William; Smith, Lewis J; Solway, Julian; Sorkness, Christine A.

N Engl J Med ; 381(13): 1227-1239, 2019 09 26.

Article in English | MEDLINE | ID: mdl-31553835

17.

Multi-ancestry genome-wide association study of asthma exacerbations.

Herrera-Luis, Esther; Ortega, Victor E; Ampleford, Elizabeth J; Sio, Yang Yie; Granell, Raquel; de Roos, Emmely; Terzikhan, Natalie; Vergara, Ernesto Elorduy; Hernandez-Pacheco, Natalia; Perez-Garcia, Javier; Martin-Gonzalez, Elena; Lorenzo-Diaz, Fabian; Hashimoto, Simone; Brinkman, Paul; Jorgensen, Andrea L; Yan, Qi; Forno, Erick; Vijverberg, Susanne J; Lethem, Ryan; Espuela-Ortiz, Antonio; Gorenjak, Mario; Eng, Celeste; González-Pérez, Ruperto; Hernández-Pérez, José M; Poza-Guedes, Paloma; Sardón, Olaia; Corcuera, Paula; Hawkins, Greg A; Marsico, Annalisa; Bahmer, Thomas; Rabe, Klaus F; Hansen, Gesine; Kopp, Matthias Volkmar; Rios, Raimon; Cruz, Maria Jesus; González-Barcala, Francisco-Javier; Olaguibel, José María; Plaza, Vicente; Quirce, Santiago; Canino, Glorisa; Cloutier, Michelle; Del Pozo, Victoria; Rodriguez-Santana, Jose R; Korta-Murua, Javier; Villar, Jesús; Potocnik, Uros; Figueiredo, Camila; Kabesch, Michael; Mukhopadhyay, Somnath; Pirmohamed, Munir.

Pediatr Allergy Immunol ; 33(6): e13802, 2022 06.

Article in English | MEDLINE | ID: mdl-35754128

18.

Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of Chronic Obstructive Pulmonary Disease.

Woo, Han; Brigham, Emily P; Allbright, Kassandra; Ejike, Chinedu; Galiatsatos, Panagis; Jones, Miranda R; Oates, Gabriela R; Krishnan, Jerry A; Cooper, Christopher B; Kanner, Richard E; Bowler, Russell P; Hoffman, Eric A; Comellas, Alejandro P; Criner, Gerard; Barr, R Graham; Martinez, Fernando J; Han, MeiLan; Ortega, Victor E; Parekh, Trisha M; Christenson, Stephanie; Belz, Daniel; Raju, Sarath; Gassett, Amanda; Paulin, Laura M; Putcha, Nirupama; Kaufman, Joel D; Hansel, Nadia N.

Am J Respir Crit Care Med ; 204(5): 536-545, 2021 09 01.

Article in English | MEDLINE | ID: mdl-33971109

19.

Benefits of Airway Androgen Receptor Expression in Human Asthma.

Zein, Joe G; McManus, Jeffrey M; Sharifi, Nima; Erzurum, Serpil C; Marozkina, Nadzeya; Lahm, Timothy; Giddings, Olivia; Davis, Michael D; DeBoer, Mark D; Comhair, Suzy A; Bazeley, Peter; Kim, Hyun Jo; Busse, William; Calhoun, William; Castro, Mario; Chung, Kian Fan; Fahy, John V; Israel, Elliot; Jarjour, Nizar N; Levy, Bruce D; Mauger, David T; Moore, Wendy C; Ortega, Victor E; Peters, Michael; Bleecker, Eugene R; Meyers, Deborah A; Zhao, Yi; Wenzel, Sally E; Gaston, Benjamin.

Am J Respir Crit Care Med ; 204(3): 285-293, 2021 08 01.

Article in English | MEDLINE | ID: mdl-33779531

20.

Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes.

Ejike, Chinedu O; Woo, Han; Galiatsatos, Panagis; Paulin, Laura M; Krishnan, Jerry A; Cooper, Christopher B; Couper, David J; Kanner, Richard E; Bowler, Russell P; Hoffman, Eric A; Comellas, Alejandro P; Criner, Gerard J; Barr, R Graham; Martinez, Fernando J; Han, MeiLan K; Martinez, Carlos H; Ortega, Victor E; Parekh, Trisha M; Christenson, Stephanie A; Thakur, Neeta; Baugh, Aaron; Belz, Daniel C; Raju, Sarath; Gassett, Amanda J; Kaufman, Joel D; Putcha, Nirupama; Hansel, Nadia N.

Am J Respir Crit Care Med ; 203(8): 987-997, 2021 04 15.

Article in English | MEDLINE | ID: mdl-33007162

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